Loading... Please wait...

Our Newsletter

The Miracle of OPC-165

[Download in printable PDF format]

After 50 years of research regarding the health benefits of OPC's (called Pycnogenol® by the original researcher, Dr. Jacques Masquelier) any discussion of this substance and its significant health benefits will sound exaggerated. Following is a brief list of the health benefits of OPC’s (oligomeric proanthocyanidin).

  • Acts as a superior antioxidant, protecting cells in the body against free radical destruction of cells.
  • Lowers LDL cholesterol levels and reduces chemical alteration of LDL’s, thus reducing the risk of cardiovascular disease.
  • Reduces platelet aggregation, thus reducing the risk of atherosclerosis.
  • Increases the strength and elasticity of blood vessels, protecting against rupture, leakage and degeneration.
  • Enhances the ability of collagen to repair itself, thereby protecting against age-related and degenerative processes.
  • Inhibits swelling (edema) and inflammation.
  • Relieves functional problems of varicose veins.
  • Reduces discomfort associated with PMS and menopause.
  • Reduces tendency toward diabetic retinopathy.
  • Improves skin health by reducing damage, increasing nutrient supply and improving elasticity.
  • Reduces the effects of allergies.
  • Improves joint flexibility.
  • Reduces the risk of more than 80 radical related diseases.
  • Reduces bruising.
  • Treats chronic venous insufficiency and reduces risk of phlebitis.
  • Improves skin elasticity and smoothness.
  • Effective against psoriasis and protects against sun damage.
  • Effective in the treatment of ADD/ADHD.
  • Aids in reducing MS exacerbations.
  • Has been shown effective in Parkinson’s and Alzheimer’s.
  • Protects against viral infections.

We told you that these benefits would sound exaggerated and implausible but those who have tried OPC’s will never deny their importance. So much research is yet to be done on the effects of OPC’s but we present the following information for your edification and can only suggest you try it yourself.


In 1947 the renowned French chemist, Jacques Masquelier chanced upon the journals of the explorer Jacques Cartier in which Cartier related how he and his crew were marooned in the St. Lawrence River by the early arrival of winter 1595. Being unprepared for the severe winter of Quebec, their food quickly ran out and there was an outbreak of scurvy that was killing his crew. A local Indian chief told Cartier that an infusion made from the bark of a pine tree would cure his crew. He tried it and recorded in his journal that his crew rapidly recovered. The story set Dr. Masquelier on the journey to find what could have been in this concoction. He knew that there could not have been enough vitamin C in the bark so he looked for something else. What he found was a mixture of bioflavonoids, including catechins and flavons, but with a particularly potent element called proanthocyanidin.

He isolated the first OPC from the red skin of the peanut and later discovered that virtually all plants, red wine and the peanut kernel itself contain oligomeric proanthocyanidins.

He coined the word Pycnogenol (from the Greek pycno meaning to condense, gen meaning to generate, and ol from the chemical name) to describe the mixture and began marketing it in Europe in the mid 1950’s.

For 50 years research and human studies conducted through scientific institutes, hospitals and clinics by dietitians and specialists has documented the positive results obtained with OPC’s. Still, the information remains new to many, including health professionals. While the pace of antioxidant research is progressing, it hasn’t been an easy accomplishment. In the 1970’s, whenever the health benefits of antioxidants were discussed, medical professionals would scoff at the idea that so many conditions could be alleviated or prevented with antioxidants. The health community did not understand how free radicals attack the body and could be the cause of over 80 diseases. Nor did they understand how antioxidant nutrients protected against free-radical damage. Without this information, it was impossible for them to understand how antioxidants protected us from so many different diseases. Thus the typical reaction was disbelief and ridicule.

Fortunately, through the years many research reports appeared in medical and scientific journals. Now cardiologists, oncologists and many other medical specialists and health professionals understand how one group of nutrients can protect us against so many different and seemingly unrelated diseases.

Interestingly, in a recent AMA survey, over 70% of practicing cardiologists admitted taking antioxidants but did not recommend them to their patients.


OPC’s are especially good at neutralizing the hydroxyl radical, the superoxide radical, singlet oxygen, and the dangerous chemical peroxynitrate. What makes peroxynitrate so dangerous is that it reacts with anything; fats, proteins, DNA, etc. It doesn’t really matter what…peroxynitrate reacts!

Excessive nitric oxide production is associated with arthritis, diabetes, stroke, septic shock, chronic inflammation and atherosclerosis. The damage it does can easily lead to gene mutations, which replicate themselves as the beginnings of cancer.

The good news is that OPC’s are exceptional at neutralizing peroxynitrate. It also reduces the amount of superoxide available that makes peroxynitrate and helps to regulate nitric oxide production so it remains in balance. That means your immune system works better, your joints hurt less and your blood flows better, all because of one single substance. Other antioxidants may help, but researchers have noticed such broad based activities are only available in OPC’s.

Researchers discovered that even when the immune system was barely working, OPC’s brought it back. Research in this direction may be very significant for those interested in autoimmune diseases.


At an annual meeting of scientists involved in OPC research, several studies were presented to substantiate claims that OPC’s combat aging and heart disease. David F. Fitzpatrick, associate professor of pharmacology and therapeutics at the University of South Florida College of Medicine in Tampa, reported that the supplement can prevent damage to blood vessels and a decrease in blood clotting, both of which are linked to heart disease. Another study found that OPC’s unique combination of natural vitamin-like compounds known as flavonoids, inhibit excessive metabolizing of nitric oxide, a process that has been linked to inflammation, arthritis and Alzheimer’s. What’s more, research conducted on mice at the University of Arizona at Tucson showed that OPC’s stimulate immune activity and delays such age-related changes as hair loss and skin damage. Studies have shown that OPC’s are non-toxic and have no known drug interactions.

Since OPC is an antioxidant, research shows it fights cholesterol by discouraging deposits from forming on artery walls. OPC’s anti-inflammatory activity may help relieve inflammatory conditions, including arthritis, allergies, bronchitis and asthma. OPC’s also correct dangerous blood clotting tendencies that trigger heart attacks and strokes. Dr. Ronald Watson, a researcher at the University of Arizona, recently confirmed that OPC’s normalize platelet aggregation, a disorder that in which the “sticky” platelets tend to form blood clots. He showed that when people smoked, their platelets clump together in a tendency to form clots. But, about 20 minutes after taking OPC’s, their platelets returned to normal.

A surprising use of OPC’s has arisen among people suffering from a bewildering disorder in concentration and attention known as Attention Deficit Disorder (ADD) or Attention Deficit Hyperactivity Disorder (ADHD). It is said to have been discovered quite by accident when people with ADD took OPC for another purpose, such as allergies, they noticed an improvement in concentration and mental focus, classic symptoms of ADD. Other started using it. Word spread and the ADD remedy has achieved high visibility.

The use of OPC’s for this purpose has not yet been widely studied but a preliminary study by Marion Sigurdson, Ph.D., a psychologist in Tulsa, Oklahoma, who specializes in treating ADD, has found striking benefits from OPC’s.

Her protocol includes the same blend utilized by Life Sources, Inc. Dr. Sigurdson found that it worked just as well as the commonly prescribed stimulant medications, including Ritalin, on 30 children and adults diagnosed with ADD.

The subjects were given a battery of computerized and behavior tests to judge their attention, concentration and other important factors in ADD under various circumstances: when they were either on or off their usual stimulant medications, or on OPC’s alone. When they were off their medications, their ADD deteriorated. On their medications, they were much improved. But when they took daily doses of the OPC mixture, their scores and behavior were just as improved as when they took stimulant drugs.

In other words, OPC’s equaled the drugs in most subjects. The subjects also had decreased heart beat, disappearance of tennis elbow, relief of acne and improved sleep and mood.

How could such a mundane combination of common grape seed and pine bark have such a profound influence on the brain comparable to that of a powerful pharmaceutical drug? According to Marcia Zimmerman, a California consultant who specializes in research on OPC’s, there is some underpinning in the scientific literature, suggesting possible mechanisms of action. A fascinating way OPC’s might affect brain cells, as shown by studies in cell cultures, she says, is by regulating enzymes that help control two crucial neurotransmitters; dopamine and norepinephrine, chemicals that carry messages among brain cells and are involved in”ecitatory” responses. OPC’s also help deliver nutrients to the brain such as zinc, manganese, selenium and copper, that are helpful in ADHD, according to recent research. Additionally, OPC’s remarkable antioxidant activity may help stabilize brain cells and improve their functioning by neutralizing damage from free radicals.

Medical studies conducted at the University of Illinois demonstrate that OPC’s antioxidant and anti-inflammatory effects have the ability to inhibit all three phases of the cancer process: initiation, promotion, and progression.

Scientists at the University of Arizona discovered that OPC’s help build resistance to cancer by as much as 40 to 50 percent by boosting the body’s first line of cancer defense, known as natural killer cells (NK cells).

Dr. Packer has focused much of his attention on the relationship between OPC’s and nitrous oxide (NO), a free radical produced in the body. Within the body, NO is a double edged immunity sword, made by the body to regulate the muscle tone of blood vessels and employed as a weapon to kill pathogens, the micro-organisms that cause disease. The body’s overproduction of NO, on the other hand, can result in chronic, damaging inflammation, the root cause of 1 in 3 cancers. “OPC’s says Dr. Packer, have a biphasic effect on NO. It both quenches NO when this substance threatens to become a damaging free radical and it inhibits a gene that might otherwise foster enzymes that can lead to NO overproduction.”

Preliminary studies have also shown that OPC’s are also effective against Alzheimer’s disease. Cell culture studies have shown that OPC’s can inhibit beta-amyloid accumulation also called amyloid-beta-protein, a peptide that accumulates in the form of plaques in the central nervous system. These plaques are a characteristic feature of Alzheimer’s disease. Beta-amyloid is directly toxic to nerve cells causing a breaking of membranes.

Dr. D. Schubert of the Salk Institute of Biological Sciences of San Diego accumulated brain cell cultures taken from Alzheimer’s patients to which beta-amyloid has been added. In those cultures, OPC’s prevented the toxic protein present in Alzheimer’s patients from accumulating.

Somewhat more impressive are reports from patients having Newman-Pick’s disease, an ailment closely related to Alzheimer’s. These patients reported significant improvement following OPC supplementation.


1. Reduces free-radical-caused tissue damage many times more effectively than vitamin E, potentiates the health-giving effects of vitamin C and protects brain and nerve tissue with its nearly unique ability to penetrate the blood-brain barrier.

2. It reduces inflammation and improves circulation, both relieving the distresses of arthritis, diabetes and stroke and promoting prevention of cardiovascular disease and cancer.

3. Its ability to bond to collagen promotes renewed youthfulness, flexibility and body integrity allowing it to function as an “oral cosmetic.”

Most importantly, OPC’s are not drugs and are as safe to use as vitamin C. What’s more, OPC’s are far less costly than pharmaceuticals. However, as an anti-oxidant formula it is 20 times more powerful than vitamin C and 50 times more so than vitamin E.


The first description of the free radical theory was noted by Dr. Denham Harman, who declared that a ‘single common process, modifiable by genetic and environmental factors, was responsible for aging and the death of all living things.’ He identified this process remarking, ‘Aging is caused by free radical reactions, which may be caused by the environment, from disease and intrinsic reactions within the aging process.’ Dr. Harman’s conclusion, written more than forty years ago, sums up much of what we finally agree upon today. He may well be called the Father of Anti-Aging medicine.


Most individuals take 1 mg per pound of body weight. For example, a 165-pound person would take 165 mg per day. It is however, common to take more since research shows that even dosages as high as 30,000 mgs. per day show no signs of toxicity or side effects.

We do recommend that individuals use a saturation dosage as follows:

1. Begin with 1 capsule 3 times a day and drink plenty of pure water to help flush toxins from the system. If you experience any signs of DETOXIFICATION (often referred to as a Herxheimer’s or health reaction) reduce your dosage and slow the saturation build up.

2. Maintain the saturation dosage for 30 days. Remain on saturation level until you reach your desired health level.

3. If your progress is not satisfactory after 30 days of saturation, increase your dose by 2X and continue until you reach your goal.

4. You may finally reduce your dosage to a maintenance level when you are satisfied with your health. Your maintenance level is best determined by yourself or your health consultant, but should not go below the level that allows symptoms to return.

On February 17, 1998, a U.S. Patent (Patent # 5,719,178) was awarded Dr. Masquelier for his discovery of Pycnogenol as a treatment for ADD/ADHD and another (Patent # 4,698,360) states “The invention provides a method of preventing and fighting the harmful biological effects of free radicals in the organism of warm blooded animals and more especially human beings, namely cerebral involution, hypoxia following atherosclerosis, cardiac or cerebral infarction, tumor promotion, inflammation, ischemia, alterations of the synovial liquid, collagen degradation, among others. The method consists of administering to said animals and especially to human beings an amount, efficient against said effects, of a plant extract with a proanthocyanidins content which has a radical scavenger effect, the extract being in the form of a medicament and coming more especially from the bark of conifers.”

To avoid conflicts of patent rights, many companies simply bottle grape seed extract or pine bark and market it as such often at huge mark ups. This ignores the volumes of research done by Dr. Masquelier and scientists from around the world.

Do not be fooled! Be sure you take a product that contains at least two (and preferably three) of the substances in the Life Sources OPC. Why pay more for less? Life Sources, Inc. has taken the process a step further in that we include 75 mg. of pine bark, 75 mg. of grape seed extract and 15 mg. of quercetin and combined them into a single capsule at one third the price of others available.